岡山大学大学院 医歯薬学総合研究科

岡山大学大学院 医歯薬学総合研究科 呼吸器・乳腺内分泌外科(第二外科)

呼吸器・乳腺内分泌外科教室


GENERAL THORACIC SURGERY AND BREAST AND ENDOCRINOLOGICAL SURGERY
トップページ 呼吸器・乳腺内分泌外科教室

呼吸器・乳腺内分泌外科教室

呼吸器・乳腺内分泌外科教室とは

呼吸器・乳腺内分泌外科教室 トップ写真

 岡山大学大学院医歯薬学総合研究科呼吸器・乳腺内分泌外科(第2外科)は大正12年に開講し、現在同門会員723名を擁する大外科学教室です。とくに関連病院(各地の基幹病院)に関しては中四国随一の質および数を誇っています。砂田輝武、寺本滋前教授時代は心臓血管外科とともに呼吸器、消化器、内分泌、輸液と幅広い分野で学会をリードしてきた実績があります。平成2年4月に心臓血管外科が独立しましたが、消化器、呼吸器、内分泌、輸液の分野は呼吸器・乳腺内分泌外科に引き継がれており、心臓血管外科は現在も兄弟科としてお互いに協力しあって診療・研究を行っています。

詳しくはこちら

当科の歴史

 1923年(大正12年)11月に西川義英教授が欧米留学より帰国し、第二外科学教室を創設してから実に80年以上の歴史を持つ「岡山大学大学院医歯薬学総合研究科呼吸器・乳腺内分泌外科」の歴代の教授と教室の沿革についてご紹介いたします。

詳しくはこちら

教職員紹介

 自由と活気のある若さあふれる教室である「呼吸器・乳腺内分泌外科教室」の教職員を紹介いたします。「鬼手仏心」:外科医は残酷なほど大胆に手術するが、それは患者を治そうとするやさしい心によるものだ、ということを銘として切磋琢磨しながらも仕事を離れると大変和気あいあいとした雰囲気で教室員一同みんな仲がよいのが特徴です。

詳しくはこちら

最近の業績

2021年以降

  • Shimizu D, Otani S, Sugimoto S, et al. Effect of preoperative long-term use of corticosteroids on the development of post-transplant lymphoproliferative disorders after lung transplantation: a single-center experience in Japan. Surg Today. 2021 Oct 25. doi: 10.1007/s00595-021-02390-7.
  • Tomioka Y, Otani S, Tanaka S, et al. Lung transplantation for idiopathic multicentric Castleman disease: potential efficacy and tolerability of a humanized anti-interleukin-6 receptor monoclonal antibody. Surg Case Rep. 2021 Sep 17;7(1):209. doi: 10.1186/s40792-021-01297-2.
  • Nakata K, Okazaki M, Shimizu D, et al. Protective effects of anti-HMGB1 monoclonal antibody on lung ischemia reperfusion injury in mice. Biochem Biophys Res Commun. 2021 Oct 8;573:164-170. doi: 10.1016/j.bbrc.2021.08.015.
  • Okazaki M, Suzawa K, Shien K, et al. Robot-assisted thoracoscopic lobectomy for severe incomplete interlober fissure. J Surg Case Rep. 2021 Aug 14;2021(8):rjab336. doi: 10.1093/jscr/rjab336.
  • Shiotani T, Sugimoto S, Yamamoto H, et al. Emphysematous changes and lower levels of plasma irisin are associated with bronchiolitis obliterans syndrome after bilateral living-donor lobar lung transplantation. Surg Today. 2021 Jul 12. doi: 10.1007/s00595-021-02339-w.
  • Shimizu D, Otani S, Sugimoto S, et al. Lung transplantation for bronchiectasis due to hyper-immunoglobulin E syndrome. Ann Thorac Surg. 2021 Jul 2:S0003-4975(21)01094-8. doi: 10.1016/j.athoracsur.2021.05.088.
  • Miura A, Yamada D, Nakamura M, et al. Oncogenic potential of human pluripotent stem cell-derived lung organoids with HER2 overexpression. Int J Cancer. 2021 Oct 15;149(8):1593-1604. doi: 10.1002/ijc.33713.
  • Kurosaki T, Oto T, Otani S, et al. Hybrid Lung Transplantation" Combining Living Donor and Cadaveric Lung Transplants: Report of 2 Cases. Transplant Proc. 2021 Jul-Aug;53(6):2004-2007. doi: 10.1016/j.transproceed.2021.04.019.
  • Okazaki M, Takigawa T, Suzawa K, Toyooka S. Robot-assisted intrathoracic procedure for dumbbell tumour in the prone position. Interact Cardiovasc Thorac Surg. 2021 Oct 4;33(4):643-645. doi: 10.1093/icvts/ivab117.
  • Miyahara K, Miyoshi K, Kurosaki T, et al. Circulating anti-human leukocyte antigen IgM antibodies as a potential early predictor of allograft rejection and a negative clinical outcome after lung transplantation. Surg Today. 2021 May 7. doi: 10.1007/s00595-021-02293-7.
  • Yamane M, Toyooka S. Role of surgery in a novel multimodal therapeutic approach to complete cure of advanced lung cancer: current and future perspectives. Surg Today. 2021 Mar 18. doi: 10.1007/s00595-021-02228-2.
  • Shiotani T, Yamamoto H, Katsube R, et al. Successful Bronchoscopic Treatment for Postoperative Bronchopleural Fistula Using N-butyl-2-cyanoacrylate (NBCA): Report of a Post-completion Pneumonectomy Case with a History of Induction Chemoradiotherapy Followed by Bilobectomy for Advanced Lung Cancer. Acta Med Okayama. 2021 Feb;75(1):91-94. doi: 10.18926/AMO/61440.
  • Shiotani T, Sugimoto S, Araki K, et al. Long-term Follow-up of Living-Donor Kidney Transplantation after Cadaveric Lung Transplantation. Acta Med Okayama. 2021 Feb;75(1):87-89. doi: 10.18926/AMO/61439.
  • Tsudaka S, Yamamoto H, Sato H, Toyooka S. ASO Author Reflections: Impact of the Postoperative Neutrophil-to-Lymphocyte Ratio in Locally Advanced Non-small Cell Lung Cancer Treated with Induction Chemoradiotherapy Followed by Surgery. Ann Surg Oncol. 2021 Sep;28(9):4891-4892. doi: 10.1245/s10434-021-09699-0.
  • Tsudaka S, Yamamoto H, Sato H, et al. Prognostic Significance of Neutrophil-to-Lymphocyte Ratio in Locally Advanced Non-small-cell Lung Cancer Treated with Trimodality Therapy. Ann Surg Oncol. 2021 Sep;28(9):4880-4890. doi: 10.1245/s10434-021-09690-9.
  • Yamamoto H, Sugimoto S, Soh J, et al. The prognostic nutritional index is correlated negatively with the lung allocation score and predicts survival after both cadaveric and living-donor lobar lung transplantation. Surg Today. 2021 Oct;51(10):1610-1618. doi: 10.1007/s00595-021-02244-2.
  • Miura A, Yamamoto H, Sato H, et al. The prognostic impact of sarcopenia on elderly patients undergoing pulmonary resection for non-small cell lung cancer. Surg Today. 2021 Jul;51(7):1203-1211. doi: 10.1007/s00595-020-02221-1.
  • Nakata K, Sugimoto S, Yamane M, Toyooka S. Staged surgery for empyema and lung gangrene caused by pseudoaneurysm after radiofrequency ablation. Interact Cardiovasc Thorac Surg. 2021 May 10;32(5):831-833. doi: 10.1093/icvts/ivaa331.
  • Yamamoto H, Yamamoto H, Soh J, et al. A Simple Prognostic Benefit Scoring System for Sarcoma Patients with Pulmonary Metastases: Sarcoma Lung Metastasis Score. Ann Surg Oncol. 2021 Jul;28(7):3884-3890. doi: 10.1245/s10434-020-09272-1.
  • Kawada K, Taira N, Mizoo T, et al. Relationships of physical and breast cancer phenotypes with three single-nucleotide polymorphisms (rs2046210, rs3757318, and rs3803662) associated with breast cancer risk in Japanese women. Breast Cancer. 2021 Mar;28(2):478-487. doi: 10.1007/s12282-020-01185-x.
  • Araki K, Kinoshita R, Tomonobu N, et al. The heterodimer S100A8/A9 is a potent therapeutic target for idiopathic pulmonary fibrosis. J Mol Med (Berl). 2021 Jan;99(1):131-145. doi: 10.1007/s00109-020-02001-x.
  • Yamamoto H, Otani S, Miyoshi K, et al. Long-term clinical follow-up after lung transplantation in patient with scoliosis: a case report. Gen Thorac Cardiovasc Surg. 2021 Apr;69(4):752-755. doi: 10.1007/s11748-020-01539-4.
  • Yamamoto H, Yamamoto H, Toyooka S. A New Scoring System for Predicting the Survival of Sarcoma Patients with Pulmonary Metastases: Sarcoma Lung Metastasis Score. Ann Surg Oncol. 2021 Jul;28(7):3891-3892. doi: 10.1245/s10434-020-09299-4.
  • Miura A, Shien K, Toji T, et al. A Giant Thymic Cyst Accompanied by Acute Mediastinitis. Acta Med Okayama. 2020 Oct;74(5):431-433. doi: 10.18926/AMO/60804.
  • Soh J, Sugimoto S, Namba K, et al. Chronic Lung Injury After Trimodality Therapy for Locally Advanced Non-Small Cell Lung Cancer. Ann Thorac Surg. 2021 Jul;112(1):279-288. doi: 10.1016/j.athoracsur.2020.07.068.
  • Sato H, Offin M, Kubota D, et al. Allele-Specific Role of ERBB2 in the Oncogenic Function of EGFR L861Q in EGFR-Mutant Lung Cancers. J Thorac Oncol. 2021 Jan;16(1):113-126. doi: 10.1016/j.jtho.2020.09.019.
  • Hatono M, Ikeda H, Suzuki Y, et al. Effect of isoflavones on breast cancer cell development and their impact on breast cancer treatments. Breast Cancer Res Treat. 2021 Jan;185(2):307-316. doi: 10.1007/s10549-020-05957-z. Epub 2020 Oct 9.
  • Yamamoto H, Sugimoto S, Miyoshi K, et al. Lung transplantation for Kartagener syndrome: technical aspects and morphological adaptation of the transplanted lungs. Gen Thorac Cardiovasc Surg. 2021 Mar;69(3):588-592. doi: 10.1007/s11748-020-01509-w.
  • Yamamoto H, Namba K, Yamamoto H, et al. The neutrophil-to-lymphocyte ratio as a novel independent prognostic factor for multiple metastatic lung tumors from various sarcomas. Surg Today. 2021 Jan;51(1):127-135. doi: 10.1007/s00595-020-02093-5.
  • Taira N, Kashiwabara K, Tsurutani J, et al. Quality of life in a randomized phase II study to determine the optimal dose of 3-week cycle nab-paclitaxel in patients with metastatic breast cancer. Breast Cancer. 2021 Sep 7:1–13. doi: 10.1007/s12282-021-01290-5.
  • Taira N, Sawaki M, Uemura Y, et al. Health-Related Quality of Life With Trastuzumab Monotherapy Versus Trastuzumab Plus Standard Chemotherapy as Adjuvant Therapy in Older Patients With HER2-Positive Breast Cancer. J Clin Oncol. 2021 Aug 1;39(22):2452-2462. doi: 10.1200/JCO.20.02751.
  • Tsukioki T, Shien T, Ohtani Y, et al. Evaluation of Prognosis of Juvenile Differentiated Thyroid Carcinoma. Acta Med Okayama. 2020 Oct;74(5):401-406. doi: 10.18926/AMO/60799.

2020年以前の業績

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2020

  • Yamane M, Sugimoto S, Suzuki E, et al. Continuing surgical education of non-technical skills. Ann Med Surg (Lond). 2020 Aug 8;58:177-186. doi: 10.1016/j.amsu.2020.07.062.
  • Soh J, Suzawa K, Shien K, et al. Prognostic nutrition index affects the prognosis of patients undergoing trimodality therapy for locally advanced non-small cell lung cancer. Surg Today. 2020 Dec;50(12):1610-1618. doi: 10.1007/s00595-020-02067-7.
  • Shikatani Y, Soh J, Shien K, et al. Effectiveness of scheduled intravenous acetaminophen in the postoperative pain management of video-assisted thoracic surgery. Surg Today. 2021 Apr;51(4):589-594. doi: 10.1007/s00595-020-02127-y.
  • Ochi K, Suzawa K, Tomida S, et al. Overcoming epithelial-mesenchymal transition-mediated drug resistance with monensin-based combined therapy in non-small cell lung cancer. Biochem Biophys Res Commun. 2020 Aug 27;529(3):760-765. doi: 10.1016/j.bbrc.2020.06.077.
  • Takahashi Y, Soh J, Shien K, et al. Fibrosis or Necrosis in Resected Lymph Node Indicate Metastasis Before Chemoradiotherapy in Lung Cancer Patients. Anticancer Res. 2020 Aug;40(8):4419-4423. doi: 10.21873/anticanres.14447.
  • Yamamoto H, Sugimoto S, Kurosaki T, et al. Lung perfusion scintigraphy to detect chronic lung allograft dysfunction after living-donor lobar lung transplantation. Sci Rep. 2020 Jun 29;10(1):10595. doi: 10.1038/s41598-020-67433-4.
  • Tsukioki T, Shien T, Tanaka T, et al. Influences of preoperative metformin on immunological factors in early breast cancer. Cancer Chemother Pharmacol. 2020 Jul;86(1):55-63. doi: 10.1007/s00280-020-04092-2.
  • Miyauchi S, Shien K, Takeda T, et al. Antitumor Effects of Pan-RAF Inhibitor LY3009120 Against Lung Cancer Cells Harboring Oncogenic BRAF Mutation. Anticancer Res. 2020 May;40(5):2667-2673. doi: 10.21873/anticanres.14237.
  • Sato H, Schoenfeld AJ, Siau E, et al. MAPK Pathway Alterations Correlate with Poor Survival and Drive Resistance to Therapy in Patients with Lung Cancers Driven by ROS1 Fusions. Clin Cancer Res. 2020 Jun 15;26(12):2932-2945. doi: 10.1158/1078-0432.CCR-19-3321.
  • Yamane M, Mandai Y, Ino H, et al. A Surgical Instructor Training Course for the Next Generation. Acta Med Okayama. 2020 Feb;74(1):73-76. doi: 10.18926/AMO/57956.
  • Yamamoto H, Miyoshi K, Otani S, et al. Right single lung transplantation using an inverted left donor lung: interposition of pericardial conduit for pulmonary venous anastomosis - a case report. BMC Pulm Med. 2020 Feb 19;20(1):46. doi: 10.1186/s12890-020-1075-4.
  • Sugimoto S, Soh J, Suzawa K, et al. Pulmonary aspergillosis as a late complication after surgery for locally advanced non-small cell lung cancer treated with induction chemoradiotherapy. Surg Today. 2020 Aug;50(8):863-871. doi: 10.1007/s00595-020-01960-5.
  • Shien T, Iwata H. Adjuvant and neoadjuvant therapy for breast cancer. Jpn J Clin Oncol. 2020 Mar 9;50(3):225-229. doi: 10.1093/jjco/hyz213.

2019

  • Takeda T, Yamamoto H, Suzawa K, et al. YES1 activation induces acquired resistance to neratinib in HER2-amplified breast and lung cancers.Cancer Sci. 2020 Mar;111(3):849-856. doi: 10.1111/cas.14289.
  • Yoshioka T, Shien K, Takeda T, et al. Acquired resistance mechanisms to afatinib in HER2-amplified gastric cancer cells.Cancer Sci. 2019 Aug;110(8):2549-2557. doi: 10.1111/cas.14089.
  • Irie M, Otani S, Kurosaki T, et al. Warm retrograde perfusion can remove more fat from lung grafts with fat embolism in a porcine model. Gen Thorac Cardiovasc Surg. 2020 Apr;68(4):363-369. doi: 10.1007/s11748-019-01245-w.
  • Nishiyama K, Taira N, Mizoo T, et al. Influence of breast density on breast cancer risk: a case control study in Japanese women. Breast Cancer. 2020 Mar;27(2):277-283. doi: 10.1007/s12282-019-01018-6.
  • Sugimoto S, Kurosaki T, Otani S, et al. Feasibility of lung transplantation from donors mechanically ventilated for prolonged periods Surg Today. 2019 Mar;49(3):254-260. doi: 10.1007/s00595-018-1730-z.
  • Tanaka S, Sugimoto S, Soh J, et al. Long-term outcomes of pneumonectomy, back-table lung preservation, double-sleeve resection and reimplantation for advanced central lung cancer: the Oto procedure. Eur J Cardiothorac Surg. 2019 Jul 1;56(1):213-214. doi: 10.1093/ejcts/ezy431.
  • Tanaka S, Miyoshi K, Higo H, et al. Lung transplant candidates with idiopathic pulmonary fibrosis and long-term pirfenidone therapy: Treatment feasibility influences waitlist survival. Respir Investig. 2019 Mar;57(2):165-171. doi: 10.1016/j.resinv.2018.12.002.
  • Mesaki K, Yamane M, Sugimoto S, et al. SOCS3 overexpression in T cells ameliorates chronic airway obstruction in a murine heterotopic tracheal transplantation model Surg Today. 2019 May;49(5):443-450. doi: 10.1007/s00595-018-1753-5.
  • Taka H, Miyoshi K, Kurosaki T, et al. Lung transplantation via cardiopulmonary bypass: excellent survival outcomes from extended criteria donors Gen Thorac Cardiovasc Surg. 2019 Jul;67(7):624-632. doi: 10.1007/s11748-019-01067-w.
  • Hirano Y, Sugimoto S, Yamamoto S, et al. Prolonged warm ischemia exacerbated acute rejection after lung transplantation from donation after cardiac death in a mouse Gen Thorac Cardiovasc Surg. 2020 Jan;68(1):57-62. doi: 10.1007/s11748-019-01181-9.
  • Hashimoto K, Yamane M, Sugimoto S, et al. Negative impact of recipient SPRED2 deficiency on transplanted lung in a mouse model Transpl Immunol. 2019 Dec;57:101242. doi: 10.1016/j.trim.2019.101242.
  • Suzawa K, Offin M, Lu D, et al. Activation of KRAS Mediates Resistance to Targeted Therapy in MET Exon 14-mutant Non-small Cell Lung Cancer Clin Cancer Res. 2019 Feb 15;25(4):1248-1260. doi: 10.1158/1078-0432.CCR-18-1640.
  • Suzawa K, Soh J, Takahashi Y, et al. Clinical outcome of patients with recurrent non-small cell lung cancer after trimodality therapy Surg Today. 2019 Jul;49(7):601-609. doi: 10.1007/s00595-019-1774-8.
  • Suzawa K, Offin M, Schoenfeld AJ, et al. Acquired MET Exon 14 Alteration Drives Secondary Resistance to Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor in EGFR-Mutated Lung Cancer JCO Precis Oncol. 2019;3:PO.19.00011. doi: 10.1200/PO.19.00011.
  • Miyauchi S, Shien K, Tanaka M, et al. Pulmonary resection in a prone position for lung cancer invading the spine Gen Thorac Cardiovasc Surg. 2020 Mar;68(3):298-301. doi: 10.1007/s11748-019-01113-7.
  • Sato H, Soh J, Aoe K, et al. Droplet digital PCR as a novel system for the detection of microRNA‑34b/c methylation in circulating DNA in malignant pleural mesothelioma. Int J Oncol. 2019 Jun;54(6):2139-2148. doi: 10.3892/ijo.2019.4768.
  • Namba K, Shien K, Takahashi Y, et al. Activation of AXL as a Preclinical Acquired Resistance Mechanism Against Osimertinib Treatment in EGFR-Mutant Non-Small Cell Lung Cancer Cells. Mol Cancer Res. 2019 Feb;17(2):499-507. doi: 10.1158/1541-7786.MCR-18-0628.
  • Namba K, Tomida S, Matsubara T, et al. Application of amplicon-based targeted sequencing with the molecular barcoding system to detect uncommon minor EGFR mutations in patients with treatment-naïve lung adenocarcinoma. BMC Cancer. 2019 Feb 26;19(1):175. doi: 10.1186/s12885-019-5374-1.
  • Konishi Y, Miyoshi K, Kurosaki T, et al. Airway bacteria of the recipient but not the donor are relevant to post-lung transplant pneumonia. Gen Thorac Cardiovasc Surg. 2020 Aug;68(8):833-840. doi: 10.1007/s11748-019-01273-6.
  • Kurosaki T, Otani S, Miyoshi K, et al. Favorable survival even with high disease-specific complication rates in lymphangioleiomyomatosis after lung transplantation-long-term follow-up of a Japanese center. Clin Respir J. 2020 Feb;14(2):116-123. doi: 10.1111/crj.13108. Epub 2019 Nov 28.
  • Soh J, Toyooka S, Okumura N, et al. Impact of pathological stage and histological subtype on clinical outcome of adjuvant chemotherapy of paclitaxel plus carboplatin versus oral uracil-tegafur for non-small cell lung cancer: subanalysis of SLCG0401 trial. Int J Clin Oncol. 2019 Nov;24(11):1367-1376. doi: 10.1007/s10147-019-01508-9.
  • Kurihara E, Shien K, Torigoe H, et al. Ganetespib in Epidermal Growth Factor Receptor-Tyrosine Kinase Inhibitor-resistant Non-small Cell Lung Cancer. Anticancer Res. 2019 Apr;39(4):1767-1775. doi: 10.21873/anticanres.13283.
  • Ogoshi Y, Shien K, Yoshioka T, et al. Anti-tumor effect of neratinib against lung cancer cells harboring HER2 oncogene alterations. Oncol Lett. 2019 Mar;17(3):2729-2736. doi: 10.3892/ol.2019.9908.
  • Sugimoto S, Yamamoto H, Kurosaki T, et al. Impact of chronic lung allograft dysfunction, especially restrictive allograft syndrome, on the survival after living-donor lobar lung transplantation compared with cadaveric lung transplantation in adults: a single-center experience. Surg Today. 2019 Aug;49(8):686-693. doi: 10.1007/s00595-019-01782-0.

2018

  • Yamamoto H, Yatabe Y, Toyooka S, et al. Inherited lung cancer syndromes targeting never smokers Transl Lung Cancer Res. 2018 Aug;7(4):498-504. doi: 10.21037/tlcr.2018.06.01.
  • Yamamoto H, Toyooka S, Ninomiya T, et al. Therapeutic Potential of Afatinib for Cancers with ERBB2 (HER2) Transmembrane Domain Mutations G660D and V659E Oncologist. 2018 Feb;23(2):150-154. doi: 10.1634/theoncologist.2017-0345.
  • Yamamoto H, Sugimoto S, Tanaka S, et al. A single-nucleotide polymorphism in a gene modulating glucocorticoid sensitivity is associated with the decline in total lung capacity after lung transplantation. Surg Today. 2019 Mar;49(3):268-274. doi: 10.1007/s00595-018-1717-9.
  • Toyooka S, Okumura N, Nakamura H, et al. A Multicenter Randomized Controlled Study of Paclitaxel plus Carboplatin versus Oral Uracil-Tegafur as the Adjuvant Chemotherapy in Resected Non-Small Cell Lung Cancer. J Thorac Oncol. 2018 May;13(5):699-706. doi: 10.1016/j.jtho.2018.02.015.
  • Sugimoto S, Miyoshi K, Kurosaki T, et al. Favorable survival in lung transplant recipients on preoperative low-dose, as compared to high-dose corticosteroids, after hematopoietic stem cell transplantation Int J Hematol. 2018 Jun;107(6):696-702. doi: 10.1007/s12185-018-2417-3.
  • Mesaki K, Sugimoto S, Otani S, et al. Pneumatosis intestinalis after lung transplantation for pulmonary graft-versus-host disease J Thorac Dis. 2018 Jan;10(1):E42-E45. doi: 10.21037/jtd.2017.11.121.
  • Otani S, Kurosaki T, Sugimoto S, et al. Unilateral lung transplantation using intact bilateral upper lobes J Thorac Cardiovasc Surg. 2018 Jul;156(1):e35-e38. doi: 10.1016/j.jtcvs.2018.03.003.
  • Sugimoto S, Yamane M, Otani S, et al. Airway complications have a greater impact on the outcomes of living-donor lobar lung transplantation recipients than cadaveric lung transplantation recipients Surg Today. 2018 Sep;48(9):848-855. doi: 10.1007/s00595-018-1663-6.
  • Kurosaki T, Miyoshi K, Otani S, et al. Low-risk donor lungs optimize the post-lung transplant outcome for high lung allocation score patients Surg Today. 2018 Oct;48(10):928-935. doi: 10.1007/s00595-018-1670-7.
  • Okada M, Yamane M, Yamamoto S, et al. SPRED2 deficiency may lead to lung ischemia-reperfusion injury via ERK1/2 signaling pathway activation Surg Today. 2018 Dec;48(12):1089-1095. doi: 10.1007/s00595-018-1696-x.
  • Habu T, Soh J, Toji T, et al. Myoepithelioma occurring in the posterior mediastinum harboring EWSR1 rearrangement: a case report Jpn J Clin Oncol. 2018 Sep 1;48(9):851-854. doi: 10.1093/jjco/hyy100.
  • Tanaka S, Sugimoto S, Kurosaki T, et al. Donor-derived cell-free DNA is associated with acute rejection and decreased oxygenation in primary graft dysfunction after living donor-lobar lung transplantation Sci Rep. 2018 Oct 18;8(1):15366. doi: 10.1038/s41598-018-33848-3.
  • Sugimoto S, Kurosaki T, Otani S, et al. Feasibility of lung transplantation from donors mechanically ventilated for prolonged periods Surg Today. 2019 Mar;49(3):254-260. doi: 10.1007/s00595-018-1730-z.
  • Sugimoto S Can pretransplant computed-tomographic assessment predict outcomes after lung transplantation? J Thorac Dis. 2018 Oct;10(10):5652-5654. doi: 10.21037/jtd.2018.09.51.
  • Takahashi Y, Shien K, Tomida S, et al. Comparative mutational evaluation of multiple lung cancers by multiplex oncogene mutation analysis. Cancer Sci. 2018 Nov;109(11):3634-3642. doi: 10.1111/cas.13797.
  • Sato H, Yamamoto H, Sakaguchi M, et al. Combined inhibition of MEK and PI3K pathways overcomes acquired resistance to EGFR-TKIs in non-small cell lung cancer. Cancer Sci. 2018 Oct;109(10):3183-3196. doi: 10.1111/cas.13763.
  • Sato H, Soh J, Hotta K, et al. Is Surgery after Chemoradiotherapy Feasible in Lung Cancer Patients with Superior Vena Cava Invasion? Ann Thorac Cardiovasc Surg. 2018 Jun 20;24(3):131-138. doi: 10.5761/atcs.oa.18-00027.
  • Torigoe H, Yamamoto H, Sakaguchi M, et al. Tumor-suppressive effect of LRIG1, a negative regulator of ErbB, in non-small cell lung cancer harboring mutant EGFR. Carcinogenesis. 2018 May 3;39(5):719-727. doi: 10.1093/carcin/bgy044.
  • Torigoe H, Shien K, Takeda T, et al. Therapeutic strategies for afatinib-resistant lung cancer harboring HER2 alterations. Cancer Sci. 2018 May;109(5):1493-1502. doi: 10.1111/cas.13571.
  • Yoshioka T, Shien K, Namba K, et al. Antitumor activity of pan-HER inhibitors in HER2-positive gastric cancer. Cancer Sci. 2018 Apr;109(4):1166-1176. doi: 10.1111/cas.13546.
  • Sato H, Sakaguchi M, Yamamoto H, et al. Therapeutic potential of targeting S100A11 in malignant pleural mesothelioma. Oncogenesis. 2018 Jan 24;7(1):11. doi: 10.1038/s41389-017-0017-3.
  • Miura A, Mori T, Yoshida A, et al. Primary adenocarcinoma of the trachea revealing a mucinous bronchial gland cell origin. Pathol Res Pract. 2018 May;214(5):796-799. doi: 10.1016/j.prp.2018.03.006.
  • Tanaka S, Miyoshi K, Higo H, et al. Lung transplant candidates with idiopathic pulmonary fibrosis and long-term pirfenidone therapy: Treatment feasibility influences waitlist survival. Respir Investig. 2019 Mar;57(2):165-171. doi: 10.1016/j.resinv.2018.12.002.
  • Shien T, Doihara H, Sato N, et al. Serum lipid and bone metabolism effects of Toremifene vs. Letrozole as adjuvant therapy for postmenopausal early breast cancer patients: results of a multicenter open randomized study. Cancer Chemother Pharmacol. 2018 Feb;81(2):269-275. doi: 10.1007/s00280-017-3491-6
  • Sasada S, Shien T, Iwata H, et al. Current status of postmastectomy radiation therapy in T1-2 breast cancer with limited positive lymph nodes in Japan: Japan Clinical Oncology Group Survey. Breast Cancer. 2018 Sep;25(5):626-627. doi: 10.1007/s12282-018-0855-7.
  • Takahashi Y, Shien T, Sakamoto A, et al. Current Multidisciplinary Approach to Fertility Preservation for Breast Cancer Patients. Acta Med Okayama. 2018 Apr;72(2):137-142. doi: 10.18926/AMO/55854.
  • Oka K, Shien T, Otsuka F, et al. Thyroid follicular carcinoma in a teenager: A case report. J Gen Fam Med. 2018 Jun 21;19(5):170-172. doi: 10.1002/jgf2.185.
  • Oka K, Yasuda M, Shien T, et al. A marked goiter involved in Marine-Lenhart syndrome. J Gen Fam Med. 2018 Nov 24;20(1):37-38. doi: 10.1002/jgf2.220.
  • Shien T The eligibility of primary tumor resection for de novo stage IV breast cancer patients Transl Cancer Res 2018;7(Suppl 5):S604-S607. doi: 10.21037/tcr.2018.05.28
  • Iwamoto T, Taira N, Fujisawa T, et al. Hormonal Therapy Resistant Estrogen-receptor Positive Metastatic Breast Cancer Cohort (HORSE-BC) Study : Current Status of Treatment Selection in Japan Acta Med Okayama. 2018 Aug;72(4):369-374. doi: 10.18926/AMO/56172.

2017

  • Sugimoto S, Yamane M, Miyoshi K, et al. Pulmonary artery patch for an inadequate donor atrial cuff in the absence of donor pericardium in lung transplantation Surg Today. 2017 Mar;47(3):399-401. doi: 10.1007/s00595-016-1370-0.
  • Maki Y, Toyooka S, Soh J, et al. Early postoperative complications after middle lobe-preserving surgery for secondary lung cancer Surg Today. 2017 May;47(5):601-605. doi: 10.1007/s00595-016-1413-6.
  • Okada M, Sugimoto S, Yamane M, et al. Immunoglobulin G4-related disease presenting as an intrapericardial tumor Jpn J Clin Oncol. 2017 Jan;47(1):88-89. doi: 10.1093/jjco/hyw161
  • Sugimoto S, Otani S, Ohki T, et al. Lung retransplantation in an adult 13 years after single lobar transplant in childhood Gen Thorac Cardiovasc Surg. 2017 Sep;65(9):539-541. doi: 10.1007/s11748-016-0732-2.
  • Hashimoto K, Miyoshi K, Mizutani H, et al. Successful Lung Transplantation for Pulmonary Disease Associated With Erdheim-Chester Disease Ann Thorac Surg. 2017 Jul;104(1):e13-e15. doi: 10.1016/j.athoracsur.2017.02.020.
  • Kawana S, Yamamoto H, Maki Y, et al. Reconstruction of Anterior Chest Wall with Polypropylene Mesh: Two Primary Sternal Chondrosarcoma Cases Acta Med Okayama. 2017 Jun;71(3):259-262. doi: 10.18926/AMO/55210.
  • Tanaka S, Miyoshi K, Sugimoto S, et al. Successful Lung Transplantation Using a Deceased Donor Mechanically Ventilated for Ten Months Ann Thorac Surg. 2017 Aug;104(2):e177-e179. doi: 10.1016/j.athoracsur.2017.03.019.
  • Hirano Y, Sugimoto S, Mano T, et al. Prolonged Administration of Twice-Daily Bolus Intravenous Tacrolimus in the Early Phase After Lung Transplantation Ann Transplant. 2017 Aug 11;22:484-492. doi: 10.12659/aot.904225.
  • Yamamoto H, Sugimoto S, Otani S, et al. Postoperative pyoderma gangrenosum exacerbated by granulocyte-colony stimulating factor after lung cancer surgery Jpn J Clin Oncol. 2017 Oct 1;47(10):991-992. doi: 10.1093/jjco/hyx121.
  • Shien K, Papadimitrakopoulou VA, Ruder D, et al. JAK1/STAT3 Activation through a Proinflammatory Cytokine Pathway Leads to Resistance to Molecularly Targeted Therapy in Non-Small Cell Lung Cancer Mol Cancer Ther. 2017 Oct;16(10):2234-2245. doi: 10.1158/1535-7163.MCT-17-0148.
  • Shien K, Toyooka S, Soh J, et al. Is tumor location an independent prognostic factor in locally advanced non-small cell lung cancer treated with trimodality therapy? J Thorac Dis. 2017 May;9(5):E489-E491. doi: 10.21037/jtd.2017.03.183.
  • Chen H, Shien K, Suzawa K, et al. Elacridar, a third-generation ABCB1 inhibitor, overcomes resistance to docetaxel in non-small cell lung cancer Oncol Lett. 2017 Oct;14(4):4349-4354. doi: 10.3892/ol.2017.6678.
  • Takeda T, Yamamoto H, Kanzaki H, et al. Yes1 signaling mediates the resistance to Trastuzumab/Lap atinib in breast cancer PLoS One. 2017 Feb 3;12(2):e0171356. doi: 10.1371/journal.pone.0171356.
  • Iwamoto T, Katagiri T, Niikura N, et al. Immunohistochemical Ki67 after short-term hormone therapy identifies low-risk breast cancers as reliably as genomic markers Oncotarget. 2017 Apr 18;8(16):26122-26128. doi: 10.18632/oncotarget.15385.
  • Kochi M, Iwamoto T, Niikura N, et al. Tumour-infiltrating lymphocytes (TILs)-related genomic signature predicts chemotherapy response in breast cancer Breast Cancer Res Treat. 2018 Jan;167(1):39-47. doi: 10.1007/s10549-017-4502-3.
  • Shien T, Iwata H Significance of primary lesion resection in Stage IV breast cancer Jpn J Clin Oncol. 2017 May 1;47(5):381-384. doi: 10.1093/jjco/hyx027.
  • Shien T, Tanaka T, Tanabe M, et al. Evaluation of ALDH1 expression in ipsilateral breast cancer recurrence Oncol Lett. 2017 Mar;13(3):1071-1077. doi: 10.3892/ol.2016.5538.
  • Saiga M, Taira N, Kimata Y, et al. Development of a Japanese version of the BREAST-Q and the traditional psychometric test of the mastectomy module for the assessment of HRQOL and patient satisfaction following breast surgery Breast Cancer. 2017 Mar;24(2):288-298. doi: 10.1007/s12282-016-0703-6.
  • Hara A, Taira N, Mizoo T, et al. N-acetyltransferase 2 polymorphism and breast cancer risk with smoking: a case control study in Japanese women Breast Cancer. 2017 Mar;24(2):254-262. doi: 10.1007/s12282-016-0696-1.

2016

  • Soh J, Toyooka S, Matsuo K, et al. Ethnicity affects EGFR and KRAS gene alterations of lung adenocarcinoma Oncol Lett. 2015 Sep;10(3):1775-1782. doi: 10.3892/ol.2015.3414.
  • Soh J, Okumura N, Nakata M, et al. Randomized feasibility study of S-1 for adjuvant chemotherapy in completely resected Stage IA non-small-cell lung cancer: results of the Setouchi Lung Cancer Group Study 0701 Jpn J Clin Oncol. 2016 Aug;46(8):741-7. doi: 10.1093/jjco/hyw062.
  • Sugimoto S, Miyoshi K, Yamane M, et al. Lung transplantation for diffuse panbronchiolitis: 5 cases from a single centre Interact Cardiovasc Thorac Surg. 2016 May;22(5):679-81. doi: 10.1093/icvts/ivw008.
  • Suzawa K, Toyooka S, Sakaguchi M, et al. Antitumor effect of afatinib, as a human epidermal growth factor receptor 2-targeted therapy, in lung cancers harboring HER2 oncogene alterations Cancer Sci. 2016 Jan;107(1):45-52. doi: 10.1111/cas.12845.
  • Suzawa K, Yamamoto H, Murakami T, et al. Establishment and molecular characterization of cell lines from Japanese patients with malignant pleural mesothelioma Oncol Lett. 2016 Jan;11(1):705-712. doi: 10.3892/ol.2015.3955.
  • Shien K, Toyooka S, Soh J, et al. Clinicopathological characteristics and lymph node metastasis pathway of non-small-cell lung cancer located in the left lingular division Interact Cardiovasc Thorac Surg. 2015 Jun;20(6):791-6. doi: 10.1093/icvts/ivv062.
  • Watanabe M, Yamamoto H, Hashida S, et al. Primary pulmonary melanoma: a report of two cases World J Surg Oncol. 2015 Sep 17;13:274. doi: 10.1186/s12957-015-0695-2.
  • Watanabe M, Yamamoto H, Eikawa S, et al. Study about the Efficacy of Metformin to Immune Function in Cancer Patients Acta Med Okayama. 2016 Aug;70(4):327-30. doi: 10.18926/AMO/54514.
  • Taira N, Arai M, Ito Y, et al. The Japanese Breast Cancer Society clinical practice guidelines for epidemiology and prevention of breast cancer, 2015 edition Breast Cancer. 2016 May;23(3):343-56. doi: 10.1007/s12282-016-0673-8.
  • Taira N, Fujisawa T, Araki K, et al. Cohort Study of Secondary Endocrine Therapy in Metastatic Breast Cancer with a Poor Response to Initial Endocrine Therapy J Clin Trials 6,2016
  • Ito M, Shien T, Kaji M, et al. Correlation between 18F-fluorodeoxyglucose Positron Emission Tomography/computed Tomography and Clinicopathological Features in Invasive Ductal Carcinoma of the Breast Acta Med Okayama. 2015;69(6):333-8. doi: 10.18926/AMO/53907.
  • Ito M, Shien T, Omori M, et al. Evaluation of aldehyde dehydrogenase 1 and transcription factors in both primary breast cancer and axillary lymph node metastases as a prognostic factor Breast Cancer. 2016 May;23(3):437-44. doi: 10.1007/s12282-015-0583-1.
  • Iwamoto T, Kumamaru H, Miyata H, et al. Distinct breast cancer characteristics between screen- and self-detected breast cancers recorded in the Japanese Breast Cancer Registry Breast Cancer Res Treat. 2016 Apr;156(3):485-494. doi: 10.1007/s10549-016-3770-7.
  • Iwamoto T, Kelly C, Mizoo T, et al. Relative Prognostic and Predictive Value of Gene Signature and Histologic Grade in Estrogen Receptor-Positive, HER2-Negative Breast Cancer Clin Breast Cancer. 2016 Apr;16(2):95-100.e1. doi: 10.1016/j.clbc.2015.10.004.
  • Miyoshi Y, Shien T, Ogiya A, et al. Differences in expression of the cancer stem cell marker aldehyde dehydrogenase 1 among estrogen receptor-positive/human epidermal growth factor receptor type 2-negative breast cancer cases with early, late, and no recurrence Breast Cancer Res. 2016 Jul 2;18(1):73. doi: 10.1186/s13058-016-0731-3.
  • Kimura K, Nakayama M, Naito I, et al. Human collagen XV is a prominent histopathological component of sinusoidal capillarization in hepatocellular carcinogenesis Int J Clin Oncol. 2016 Apr;21(2):302-309. doi: 10.1007/s10147-015-0888-2

2015

  • Miyoshi S, Shien K, Toyooka S, et al. Validity of using lobe-specific regional lymph node stations to assist navigation during lymph node dissection in early stage non-small cell lung cancer patients Surg Today. 2014 Nov;44(11):2028-36. doi: 10.1007/s00595-013-0772-5.
  • Tao H, Shien K, Soh J, et al. Density of tumor-infiltrating FOXP3+ T cells as a response marker for induction chemoradiotherapy and a potential prognostic factor in patients treated with trimodality therapy for locally advanced non-small cell lung cancer Ann Thorac Cardiovasc Surg. 2014;20(6):980-6. doi: 10.5761/atcs.oa.13-00237.
  • Oto T, Miyoshi K, Sugimoto S, et al. Living related donor middle lobe lung transplant in a pediatric patient J Thorac Cardiovasc Surg. 2015 Mar;149(3):e42-4. doi: 10.1016/j.jtcvs.2014.10.102.
  • Toyooka S, Soh J, Yamamoto H, et al. Extended sleeve lobectomy after induction chemoradiotherapy for non-small cell lung cancer Surg Today. 2015 Sep;45(9):1121-6. doi: 10.1007/s00595-014-1025-y.
  • Sugimoto S, Toyooka S, Suzawa K, et al. Thoracoscopic lobectomy as salvage surgery for local recurrence of non-small cell lung cancer after carbon ion radiotherapy in an initially operable patient Ann Thorac Cardiovasc Surg. 2014;20 Suppl:501-4. doi: 10.5761/atcs.cr.13-00223.
  • Sugimoto S, Oto T, Toyooka S, et al. Kissing-stents technique after living-donor lobar lung transplantation Eur J Cardiothorac Surg. 2015 Jun;47(6):1105-6. doi: 10.1093/ejcts/ezu314.
  • Sugimoto S, Tanaka M, Suzawa K, et al. Pneumocephalus and chylothorax complicating vertebrectomy for lung cancer Ann Thorac Surg. 2015 Apr;99(4):1425-8. doi: 10.1016/j.athoracsur.2014.05.098.
  • Otani H, Yamamoto H, Takaoka M, et al. TAE226, a Bis-Anilino Pyrimidine Compound, Inhibits the EGFR-Mutant Kinase Including T790M Mutant to Show Anti-Tumor Effect on EGFR-Mutant Non-Small Cell Lung Cancer Cells PLoS One. 2015 Jun 19;10(6):e0129838. doi: 10.1371/journal.pone.0129838.
  • Yamamoto H, Soh J, Ichimura K, et al. Adult mesenchymal hamartoma of the chest wall: report of a case Ann Thorac Cardiovasc Surg. 2014;20 Suppl:663-5. doi: 10.5761/atcs.cr.13-00225.
  • Otani S, Levvey BJ, Westall GP, et al. Long-term successful outcomes from kidney transplantation after lung and heart-lung transplantation Ann Thorac Surg. 2015 Mar;99(3):1032-8. doi: 10.1016/j.athoracsur.2014.11.023.
  • Otani S, Westall GP, Levvey BJ, et al. Managing central venous obstruction in cystic fibrosis recipients--lung transplant considerations J Cyst Fibros. 2015 Mar;14(2):255-61. doi: 10.1016/j.jcf.2014.08.003.
  • Miyoshi K, Oto T, Konishi Y, et al. Use of Extended-Criteria Lungs on a Lobe-by-Lobe Basis Through Ex Vivo Lung Perfusion Assessment Ann Thorac Surg. 2015;99(5):1819-21. doi: 10.1016/j.athoracsur.2014.06.115.
  • Shien K, Toyooka S, Soh J, et al. Lower lobe origin is a poor prognostic factor in locally advanced non-small-cell lung cancer patients treated with induction chemoradiotherapy Mol Clin Oncol. 2015 May;3(3):706-712. doi: 10.3892/mco.2015.509.
  • Maki Y, Fujimoto J, Lang W, et al. LAPTM4B is associated with poor prognosis in NSCLC and promotes the NRF2-mediated stress response pathway in lung cancer cells Sci Rep. 2015 Sep 7;5:13846. doi: 10.1038/srep13846.
  • Taira N, Arai M, Ikeda M, et al. The Japanese Breast Cancer Society clinical practice guideline for epidemiology and prevention of breast cancer Breast Cancer. 2015 Jan;22(1):16-27. doi: 10.1007/s12282-014-0555-x.
  • Taira N, Akiyama I, Ishihara S, et al. Impact of modifiable lifestyle factors on outcomes after breast cancer diagnosis: the Setouchi Breast Cancer Cohort Study Jpn J Clin Oncol. 2015 Jun;45(6):600-2. doi: 10.1093/jjco/hyv033.
  • Nogami T, Taira N, Toyooka S, et al. A case of carcinoma showing thymus-like differentiation with a rapidly lethal course Case Rep Oncol. 2014 Dec 20;7(3):840-4. doi: 10.1159/000370306.
  • Itoh M, Iwamoto T, Matsuoka J, et al. Estrogen receptor (ER) mRNA expression and molecular subtype distribution in ER-negative/progesterone receptor-positive breast cancers Breast Cancer Res Treat. 2014 Jan;143(2):403-9. doi: 10.1007/s10549-013-2763-z.

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